Pyridostatin hydrochloride (Synonyms: RR82 hydrochloride) |
| カタログ番号GC37043 |
ピリドスタチン (RR82) 塩酸塩は、G-四重鎖 DNA 安定剤です (Kd = 490 nM)。ピリドスタチン塩酸塩は、複製および転写依存の DNA 損傷を誘発することにより、ヒト癌細胞の増殖停止を促進します。ピリドスタチン塩酸塩は、がん原遺伝子 Src を標的とします。ピリドスタチン塩酸塩は、ヒト乳癌細胞の SRC タンパク質レベルと SRC 依存性細胞運動性を低下させました。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1781882-65-2
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Kd: 490 nM (G-quadruplexe)[1]
Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].
[1]. Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011 Aug 28;3(10):782-7. [2]. Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017 Sep 12;9(9):1957-1970. [3]. Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *