Gamma-Mangostin |
| Catalog No.GC38227 |
Gamma-Mangostin est un nouvel antagoniste compétitif des récepteurs 5-hydroxytryptamine 2A (5-HT2A), purifié À partir de la coque du fruit de la plante médicinale Garcinia mangostana.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31271-07-5
Sample solution is provided at 25 µL, 10mM.
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Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) [1].
[1]. Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31. [2]. Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.
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