HSP27 inhibitor J2 (Synonyms: J2) |
| Catalog No.GC38503 |
L'inhibiteur de HSP27 J2 (J2) est un inhibiteur de HSP27, qui induit significativement la formation anormale de dimères de HSP27 et inhibe une production de polymères géants de HSP27, ayant ainsi pour effet d'inhiber une fonction chaperonne de la HSP27 et de réduire une fonction de protection cellulaire de celle-ci. L'inhibiteur de HSP27 J2 (J2) améliore remarquablement l'activité antiproliférative du 17-AAG et sensibilise l'inhibition de la croissance des cellules cancéreuses pulmonaires induite par le cisplatine.
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Cas No.: 2133499-85-9
Sample solution is provided at 25 µL, 10mM.
HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which significantly induces abnormal HSP27 dimer formation and inhibits HSP27 macropolymer production[1-3].
J2(10 µM J2;12 hr)showed stronger HSP27 cross linking activity in HSP27 high expressed lung cancer cells and relatively low cytoxicity[4].
J2(15 mg/kg; i.p; on every other day after irradiation for 14d) treatment significantly inhibited immune cell infiltration in lung tissue. J2-treated mice reversed radiation-induced respiratory distress. J2 inhibited IR-induced lung fibrosis in mice[5-6].
References:
[1]. Hwang SY, Kwak SY, et,al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27. Eur J Med Chem. 2017 Oct 20;139:892-900. doi: 10.1016/j.ejmech.2017.08.065. Epub 2017 Sep 1. PMID: 28869891.
[2]. Garrido C, Bruey JM, et,al. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J. 1999 Nov;13(14):2061-70. doi: 10.1096/fasebj.13.14.2061. PMID: 10544189.
[3]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.
[4]. Choi B, Choi SK, et,al. Sensitization of lung cancer cells by altered dimerization of HSP27. Oncotarget. 2017 Oct 31;8(62):105372-105382. doi: 10.18632/oncotarget.22192. PMID: 29285257; PMCID: PMC5739644.
[5]. Kim JY, An YM, et,al. HSP27 inhibitor attenuates radiation-induced pulmonary inflammation. Sci Rep. 2018 Mar 8;8(1):4189. doi: 10.1038/s41598-018-22635-9. PMID: 29520071; PMCID: PMC5843649.
[6]. Kim JY, Jeon S, et,al. The Hsp27-Mediated IkBα-NFκB Signaling Axis Promotes Radiation-Induced Lung Fibrosis. Clin Cancer Res. 2019 Sep 1;25(17):5364-5375. doi: 10.1158/1078-0432.CCR-18-3900. Epub 2019 May 24. PMID: 31126962.
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