GNF-6231 |
Catalog No.GC32877 |
Le GNF-6231 est un inhibiteur de porc-épic puissant, sélectif et biodisponible par voie orale qui bloque la signalisation Wnt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1243245-18-2
Sample solution is provided at 25 µL, 10mM.
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy.
[1]. Cheng D et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett. 2016 May 10;7(7):676-80.
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