GSK8612 |
| Catalog No.GC65013 |
GSK8612 est un inhibiteur hautement sélectif et puissant de la kinase-1 de liaison au réservoir (TBK1), avec un pIC50 de 6,8 pour le TBK1 recombinant.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361659-62-1
Sample solution is provided at 25 µL, 10mM.
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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1[1].
GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING[1].
[1]. Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785.
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