GSK8612 |
| カタログ番号GC65013 |
GSK8612 は、選択性が高く強力なタンク結合キナーゼ 1 (TBK1) 阻害剤であり、組換え TBK1 の pIC50 は 6.8 です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361659-62-1
Sample solution is provided at 25 µL, 10mM.
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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1[1].
GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING[1].
[1]. Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785.
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