Hematein |
| Catalog No.GC39266 |
L'hématéine est un produit d'oxydation de l'hématoxyline qui agit comme un colorant. L'hématéine est un inhibiteur allostérique de la caséine kinase II avec une IC50 de 0,74 μM. L'hématéine inhibe la phosphorylation d'Akt/PKB Ser129, la voie Wnt/TCF et augmente l'apoptose dans les cellules cancéreuses du poumon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 475-25-2
Sample solution is provided at 25 µL, 10mM.
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Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
[1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22.
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