IKK-3 Inhibitor (Synonyms: GSK 319347A) |
| Catalog No.GC10592 |
A multi-kinase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 862812-98-4
Sample solution is provided at 25 µL, 10mM.
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An IKK-3 Inhibitor. The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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