Isocurcumenol (Synonyms: (+)-Isocurcumenol) |
Catalog No.GC48900
One-Click Copy Product Info
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L'isocurcuménol, un inhibiteur du récepteur des œstrogènes alpha (ERα) isolé des rhizomes de Curcuma zedoaria, possède une activité antitumorale, avec des valeurs IC50 de 99,1 μg/mL et 178,2 μg/mL dans les cellules DLA et KB, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 24063-71-6
Sample solution is provided at 25 µL, 10mM.
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Isocurcumenol is a sesquiterpene that has been found in C. zedoaria rhizomes and has diverse biological activities.1,2,3 It inhibits mycelial growth of the plant pathogenic fungus F. graminearum when used at a concentration of 0.5 mg/ml.1 Isocurcumenol is cytotoxic to DLA, A549, KB, and K562 cancer cells (IC50s = 75.3, 75.7, 142.2, and 45.83 µg/ml, respectively).2 It inhibits LPS-induced production of nitric oxide (NO) in isolated mouse peritoneal macrophages.3 Isocurcumenol (50 mg/kg) reduces LPS/D-galactosamine-induced increases in serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in a mouse model of liver injury.
1.Chen, C., Long, L., Zhang, F., et al.Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearumPLoS One13(3)e0194284(2018) 2.Lakshmi, S., Padmaja, G., and Remani, P.Antitumour effects of isocurcumenol isolated from Curcuma zedoaria rhizomes on human and murine cancer cellsInt. J. Med. Chem.253962(2011) 3.Matsuda, H., Ninomiya, K., Morikawa, T., et al.Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injuryBioorg. Med. Chem. Lett.8(4)339-344(1998)
| Cas No. | 24063-71-6 | SDF | |
| Synonymes | (+)-Isocurcumenol | ||
| Canonical SMILES | C=C([C@@]1([H])[C@]([C@@H](C)CC1)(O2)C/3)C[C@]2(O)C3=C(C)/C | ||
| Formula | C15H22O2 | M.Wt | 234.3 |
| Solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: slightly soluble | Storage | -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.268 mL | 21.3402 mL | 42.6803 mL |
| 5 mM | 853.6 μL | 4.268 mL | 8.5361 mL |
| 10 mM | 426.8 μL | 2.134 mL | 4.268 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)