Isocurcumenol (Synonyms: (+)-Isocurcumenol)

Isocurcumenol is a sesquiterpene that has been found in C. zedoaria rhizomes and has diverse biological activities.^1,2,3 It inhibits mycelial growth of the plant pathogenic fungus F. graminearum when used at a concentration of 0.5 mg/ml.¹ Isocurcumenol is cytotoxic to DLA, A549, KB, and K562 cancer cells (IC₅₀s = 75.3, 75.7, 142.2, and 45.83 µg/ml, respectively).² It inhibits LPS-induced production of nitric oxide (NO) in isolated mouse peritoneal macrophages.³ Isocurcumenol (50 mg/kg) reduces LPS/D-galactosamine-induced increases in serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in a mouse model of liver injury.

1.Chen, C., Long, L., Zhang, F., et al.Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearumPLoS One13(3)e0194284(2018) 2.Lakshmi, S., Padmaja, G., and Remani, P.Antitumour effects of isocurcumenol isolated from Curcuma zedoaria rhizomes on human and murine cancer cellsInt. J. Med. Chem.253962(2011) 3.Matsuda, H., Ninomiya, K., Morikawa, T., et al.Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injuryBioorg. Med. Chem. Lett.8(4)339-344(1998)