JH 295 |
| Catalog No.GC50057 |
JH 295 est un inhibiteur puissant, irréversible et sélectif de la kinase 2 (Nek2) liée à la NIMA avec une IC50 de 770 nM. JH 295 inhibe la Nek2 cellulaire via l'alkylation de Cys22. JH 295 est inactif contre les kinases mitotiques, Cdk1, Aurora B ou Plk1, et ne perturbe pas l'assemblage du fuseau bipolaire ni le point de contrôle de l'assemblage du fuseau.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1311143-71-1
Sample solution is provided at 25 µL, 10mM.
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Irreversible Nek2 inhibitor (IC50=770 nM). Inhibits Nek2 via alkylation of residue Cys22. Displays 5-fold selectivity for Nek2 over Cdk1. Exhibits no significant effect on Aurora B or Plk1 kinases, bipolar spindle assembly or spindle assembly checkpoint. Cell permeable.
Henise et al (2011) Irreversible Nek2 kinase inhibitors with cellular activity. J.Med.Chem. 54 4133 PMID:21627121
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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