JH 295 |
| Catalog No.GC50057 |
JH 295는 IC50이 770nM인 강력하고 비가역적이며 선택적 NIMA 관련 키나제 2(Nek2) 억제제입니다. JH 295는 Cys22의 알킬화를 통해 세포 Nek2를 억제합니다. JH 295는 유사분열 키나제, Cdk1, Aurora B 또는 Plk1에 대해 비활성이며 양극성 스핀들 어셈블리 또는 스핀들 어셈블리 체크포인트를 교란하지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1311143-71-1
Sample solution is provided at 25 µL, 10mM.
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Irreversible Nek2 inhibitor (IC50=770 nM). Inhibits Nek2 via alkylation of residue Cys22. Displays 5-fold selectivity for Nek2 over Cdk1. Exhibits no significant effect on Aurora B or Plk1 kinases, bipolar spindle assembly or spindle assembly checkpoint. Cell permeable.
Henise et al (2011) Irreversible Nek2 kinase inhibitors with cellular activity. J.Med.Chem. 54 4133 PMID:21627121
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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