JI051 |
| Catalog No.GC34635 |
JI051 est un stabilisateur de l'interaction Hes1-PHB2. JI051 interagit avec une protéine chaperonne prohibitine 2 (PHB2) associée au cancer, induit l'arrêt du cycle cellulaire en inhibant le gène effecteur en aval Notch Hes1. Activité anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2234281-75-3
Sample solution is provided at 25 µL, 10mM.
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JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].
JI051 causes G2/M cell-cycle arrest[1].JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells
[1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.
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