KYP 2047 |
| Catalog No.GC50403 |
Le KYP 2047 est un puissant inhibiteur de la prolyl-oligopeptidase (POP) pénétrant dans la BBB, avec une valeur Ki de 0,023 nM. Le KYP 2047 réduit la prolifération des glioblastomes par l'angiogenèse et la modulation de l'apoptose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 796874-99-2
Sample solution is provided at 25 µL, 10mM.
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High affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. Anti-angiogenic and neuroprotective. Brain penetrant.
Yedlapudi et al (2016) Inhibition of alpha-synuclein aggregation by multifunctional Da agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model. Sci Rep. 69 38510 PMID:27917933 |Myöhänen et al (2012) A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. Br.J.Pharmacol. 166 1097 PMID:22233220 |Jalkanen et al (2011) Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat. Basic Clin.Pharmacol.Toxicol. 109 443 PMID:21707925 |Myöhänen et al (2011) Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. Br.J.Pharmacol. 163 1666 PMID:21133893 |Venäläinen et al (2006) Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors. Biochem.Pharmacol. 71 683 PMID:16405869
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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