LC10 |
Catalog No.GC52394 |
A lipidoid derivative of lithocholic acid
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
LC10 is a lipidoid derivative of the secondary bile acid lithocholic acid that contains two 10-carbon alkyl chains.1 It has been used in the generation of self-assembling skin-permeable lipid nanoparticles (LNPs). LC10 LNPs inhibit the proliferation of normal human epidermal keratinocytes (NHEKs) when used at a concentration of 100 nM and reduce the levels of TNF-α, IL-17, and IL-23 in human peripheral blood mononuclear cells (PBMCs) at 50, 100, and 200 nM. Topical application of LC10 LNPs (10 mg/kg) reduces psoriatic-like plaques and reverses weight loss induced by imiquimod in a mouse model of psoriasis.
1.Rachamalla, H.K., Voshavar, C., Arjunan, P., et al.Skin-permeable nano-lithocholic lipidoid efficiently alleviates psoriasis-like chronic skin inflammationsACS Appl. Mater. Interfaces14(13)14859-14870(2022)
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *