Lenalidomide-I |
| Catalog No.GC62147 |
Le lénalidomide-I (composé 72), un analogue du ligand du cereblon (CRBN) Le lénalidomide pour l'ubiquitine ligase E3, est utilisé dans le recrutement de la protéine CRBN. Le lénalidomide-I peut être connecté au ligand de la protéine par un lieur pour former des PROTAC, tels que le dégradeur PROTAC BET QCA570.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2207541-30-6
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1].
Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.
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