Lenalidomide-I |
| Catalog No.GC62147 |
E3 유비퀴틴 리가제에 대한 세레블론(CRBN) 리간드 레날리도마이드의 유사체인 레날리도마이드-I(화합물 72)는 CRBN 단백질 모집에 사용됩니다. 레날리도마이드-I는 링커에 의해 단백질에 대한 리간드에 연결되어 PROTAC BET 분해자 QCA570과 같은 PROTAC를 형성할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2207541-30-6
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1].
Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.
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