LY 345899 |
| Katalog-Nr.GC31357 |
LY 345899 ist ein Folsäure-Analogon und ein Hemmstoff für MTHFD1 (DC301) und MTHFD2, die Methylen-Tetrahydrofolat-Dehydrogenasen sind. Die IC50-Werte betragen 96 nM bzw. 663 nM, während der Ki-Wert für MTHFD1 bei 18 nM liegt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10538-99-5
Sample solution is provided at 25 µL, 10mM.
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LY 345899 is a human cytosolic methylenetetrahydrofolate dehydrogenase/cyclohydrolase (DC301) inhibitor, with a Ki of 0.018 μM.
[1]. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35.
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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