Metamizole (sodium salt) (Synonyms: Dipyrone) |
| Catalog No.GC44167 |
Le métamizole (sel de sodium) est un composé non opioÏde doté d'excellents effets analgésiques et antipyrétiques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68-89-3
Sample solution is provided at 25 µL, 10mM.
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Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects. MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC50s = 2.6 and 20.8 µM, respectively, and COX-2: IC50s = 4.7 and 41.8 µM, respectively). These metabolites can be further acylated with arachidonic acid to form compounds that can bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors at low micromolar concentrations.
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