ML604440 |
| Catalog No.GC61075 |
ML604440 est un inhibiteur spécifique et perméable aux cellules du protéasome β1i (LMP2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1140517-08-3
Sample solution is provided at 25 µL, 10mM.
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ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naÏve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].
[1]. de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209 [2]. Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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