MS31 trihydrochloride |
| Catalog No.GC39252 |
Le trichlorhydrate de MS31 est un puissant inhibiteur de spindline 1 (SPIN1) de la protéine lecteur de méthyllysine, hautement affin et sélectif. Le trichlorhydrate de MS31 inhibe puissamment les interactions entre SPIN1 et H3K4me3 (IC50 = 77 nM, AlphaLISA ; 243 nM, FP). Le trichlorhydrate de MS31 se lie sélectivement au domaine Tudor II de SPIN1 (Kd = 91 nM). Le trichlorhydrate de MS31 inhibe puissamment la liaison des peptides contenant de la triméthyllysine À SPIN1 et n'est pas toxique pour les cellules non tumorigènes.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1].
[1]. Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.
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