N1-Me-pUTP,100mM Sodium Solution (Synonyms: 1-Methylpseudouridine-5′-triphosphate) |
| Catalog No.GB20016 |
La solution de sodium N1-Me-pUTP, 100 mM (1-méthylpseudouridine-5'-triphosphate) est un nucléotide modifié par une base nucléique, utilisé pour la synthèse d'ARN avec une immunogénicité réduite et une stabilité améliorée.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1428903-59-6
Sample solution is provided at 25 µL, 10mM.
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N1-Methylpseudo-UTP (N1-Me-pUTP, m1ψ) is a methyl modification of naturally occurring pseudouridine (pseudo-UTP, pUTP), resulting from the N1-specific pseudouridine present in archaea and eukaryotes It is catalyzed by glycoside methyltransferase Nepl[1]. N1-Me-pUTP is a substitute for uridine (U) in RNA therapies and vaccines, which can effectively enhance RNA stability while reducing anti-RNA immune responses[2].
References:
[1]. Callum J C Parr, et al.N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells. 2020 Apr 6;48(6):e35. doi: 10.1093/nar/gkaa070.
[2]. Pedro Morais, Hironori Adachi, Yi-Tao Yu.The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines. 2021 Nov 4;9:789427. doi: 10.3389/fcell.2021.789427.
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