N1-Me-pUTP,100mM Sodium Solution (Synonyms: 1-Methylpseudouridine-5′-triphosphate) |
| Catalog No.GB20016 |
N1-Me-pUTP,100mM Sodium Solution (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1428903-59-6
Sample solution is provided at 25 µL, 10mM.
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N1-Methylpseudo-UTP (N1-Me-pUTP, m1ψ) is a methyl modification of naturally occurring pseudouridine (pseudo-UTP, pUTP), resulting from the N1-specific pseudouridine present in archaea and eukaryotes It is catalyzed by glycoside methyltransferase Nepl[1]. N1-Me-pUTP is a substitute for uridine (U) in RNA therapies and vaccines, which can effectively enhance RNA stability while reducing anti-RNA immune responses[2].
References:
[1]. Callum J C Parr, et al.N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells. 2020 Apr 6;48(6):e35. doi: 10.1093/nar/gkaa070.
[2]. Pedro Morais, Hironori Adachi, Yi-Tao Yu.The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines. 2021 Nov 4;9:789427. doi: 10.3389/fcell.2021.789427.
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