NS19504 |
| Catalog No.GC38826 |
NS19504 est un activateur du canal K+ activé par Ca2+- (canal BK, canal KCa1.1) (EC50 =11,0 μM) avec un effet relaxant sur les contractions phasiques spontanées des muscles lisses de la vessie.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 327062-46-4
Sample solution is provided at 25 µL, 10mM.
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NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].
NS19504 increases BK currents in freshly isolated guinea pig bladder smooth muscle cells and whole-cell. NS19504 increases the whole-cell currents response to 127 %, 194 %, 258 %, 561 % of control at a concentration of 0.32 µM, 1.0 µM, 3.2 µM and 10 µM, respectively[1].
[1]. Nausch B, et al. NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.
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