PF 3758309 dihydrochloride (Synonyms: PF-03758309 dihydrochloride) |
| Catalog No.GC50314 |
Potent PAK4 inhibitor; orally available
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Potent PAK4 inhibitor (IC50 = 1.3 nM; Kd = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.
Murray et al (2010) Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc.Natl.Acad.Sci.U.S.A. 107 9446 PMID:20439741
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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