PHPS1 sodium salt |
Catalog No.GC50568 |
Shp2 (PTPN11) inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Shp2 (PTPN11) inhibitor (IC50 = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.
Hellmuth et al (2008) Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc.Natl.Acad.Sci.U.S.A 105 7275 PMID:18480264 |Ahrendsen et al (2018) The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J.Neurosci. 38 787 PMID:29217681 |Zehender et al (2018) The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat.Commun. 9 3259 PMID:30108215
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(Based on Reviews and 22 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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