PROTAC BRD4 Degrader-9 |
| Catalog No.GC64436 |
PROTAC BRD4 Degrader-9 (composé 8a) est un PROTAC connecté par des ligands pour von Hippel-Lindau et BRD4. PROTAC BRD4 Degrader-9 peut être conjugué avec les anticorps STEAP1 et CLL1 pour dégrader la protéine BRD4 dans les cellules cancéreuses de la prostate PC3, avec un DC50 de 0,86 nM et 7,6 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2417370-42-2
Sample solution is provided at 25 µL, 10mM.
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PROTAC BRD4 Degrader-9 (compound 8a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively[1].
[1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
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