PROTAC BRD4 Degrader-9 |
| カタログ番号GC64436 |
PROTAC BRD4 Degrader-9 (化合物 8a) は、von Hippel-Lindau および BRD4 のリガンドによって接続された PROTAC です。 PROTAC BRD4 Degrader-9 を STEAP1 および CLL1 抗体と結合させて、PC3 前立腺癌細胞の BRD4 タンパク質をそれぞれ 0.86 nM および 7.6 nM の DC50 で分解できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2417370-42-2
Sample solution is provided at 25 µL, 10mM.
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PROTAC BRD4 Degrader-9 (compound 8a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively[1].
[1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
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