PROTO-1 |
| Catalog No.GC30482 |
PROTO-1 est un protecteur des cellules ciliées et peut être utilisé dans des études sur la mort des cellules ciliées induite par l'ototoxicité.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 312951-85-2
Sample solution is provided at 25 µL, 10mM.
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PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).Target:PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with 1 and 10 μM PROTO-1 results in significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar.[2]
[1]. Rubel, et al. COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH [2]. Owens KN, et al. Identification of genetic and chemicalm modulators of zebrafish mechanosensory hair cell death. PLoS Genet. 2008 Feb 29;4(2):e1000020.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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