PZ-2891 |
| Catalog No.GC34746 |
Le PZ-2891 est un modulateur de pantothénate kinase (PANK) pénétrant dans le cerveau et biodisponible par voie orale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2170608-82-7
Sample solution is provided at 25 µL, 10mM.
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PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA. IC50: 1.3 nM (PANK)[1]
[1]. Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399.
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