RCM-1 |
| Catalog No.GC33117 |
RCM-1 est un inhibiteur de Forkhead Box M1 (FOXM1) avec une CE50 de 0,72 μM dans les cellules U2OS. RCM-1 bloque la localisation nucléaire et augmente la dégradation protéasomique de FOXM1. RCM-1 peut être utilisé pour la recherche sur l'asthme et d'autres maladies chroniques des voies respiratoires.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 339163-65-4
Sample solution is provided at 25 µL, 10mM.
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RCM-1 is a FOXM1 inhibitor.
RCM-1 inhibits cellular proliferation via increasing duration of cell cycle and mitosis in human and mouse cancer cell lines in vitro. Treatment with RCM-1 increases duration of mitosis and cell cycle in the cancer cell lines. RCM-1 inhibits colony formation of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits migration of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the initiation as well as growth of cancer cell colonies in vitro[1].
RCM-1 treatment reduces growth of Rd76-9 rhabdomyosarcomas in mice. RCM-1 treatment decreases tumor cell proliferation and increases apoptosis in Rd76-9 rhabdomyosarcoma tumors. The RCM-1-treated Rd76-9 tumors show reduced FOXM1 staining and decreased expression of proliferation-specific markers Ki67 and PH3. Cleaved caspase staining is increased in the RCM-1 treated tumors, indicating an increase in apoptosis. RCM-1 treatment reduces growth of the B16-FlO melanoma tumors in mice. RCM-1 decreases the B 16-FlO tumor growth as compared to the Vehicle -treated group. RCM-1 treatment decreases tumor cell proliferation and increased apoptosis in B16-FlO melanoma tumors. RCM-1 treatment reduces growth of the human H2122 lung adenocarcinoma in mice[1].
[1]. ARYL SULFONOHYDRAZIDES.WO2018057550A1.
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