Signaling Pathways
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The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.
ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.
The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.
References:
[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.
[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.
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Products Related to Signaling Pathways(40698)
- GC80144Aripiprazole impurity 9CAS: 57260-67-0Purity: >99.50%
Aripiprazole impurity 9 is an impurity of Aripiprazole.
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2-(6-Bromo-1H-indol-3-yl) acetonitrile is an intermediate that participates in the synthesis of MKlp2 inhibitors.
- GC80146Aripiprazole impurity 35CAS: 889443-20-3Purity: >98.00%
Aripiprazole impurity 35 is an impurity of Aripiprazole.
- GC80147Paliperidone impurity 9CAS: 260273-82-3Purity: >98.00%
Paliperidone impurity 9 is an impurity of Paliperidone.
- GC80148Albendazole impurity 9CAS: 80983-34-2Purity: >98.50%
6-(Propylsulfonyl)-1H-benzimidazol-2-amine (Albendazole-2-aminosulfone) is a drug impurity.
- GC80149FPPS ligand 3CAS: 51527-19-6Purity: >98.00%
FPPS ligand 3 (compound 2) is a farnesyl pyrophosphate synthase (FPPS) ligand.
- GC80150Paliperidone impurity 17CAS: 130049-82-0Purity: >97.00%
Paliperidone impurity 17 is an impurity of Paliperidone.
- GC80151Metoprolol impurity 3 hydrochlorideCAS: 73313-36-7Purity: >98.00%
Metoprolol impurity 3 hydrochloride is an impurity of Metoprolol hydrochloride.
- GC801522,4'-DichlorobenzophenoneCAS: 85-29-0Purity: >98.50%
2,4'-Dichlorobenzophenone is a dichlorinated benzophenone and intermediate in the synthesis of selected fungicides and other agricultural products [1] .
- GC80153H-Pro-His-OHCAS: 92027-43-5Purity: >98.00%
H-Pro-His-OH is a commonly used amino acid building block in biochemistry and peptide synthesis.
- GC80154Atenolol impurity 2CAS: 1797116-92-7Purity: >98.00%
Atenolol impurity 2 (C-Desmethyl atenolol) is an impurity of Atenolol.
- GC80155Lincomycin impurity 2CAS: 14810-93-6Purity: >98.00%
Lincomycin impurity 2 (Methyl 1-thiolincosaminide) is an impurity of Lincomycin.
- GC801563,2'-DihydroxyflavoneCAS: 6068-76-4Purity: >99.00%
3,2'-Dihydroxyflavone (Compound 4) is a type of flavonol compound that can be used as a drug intermediate for the synthesis of tetracyclic compounds [1] .
- GC80157ElymoclavineCAS: 548-43-6Purity: >98.00%
Elymoclavine, an ergot alkaloid, is a potential prolactin inhibitor.
- GC801585-Iodoindolin-2-oneCAS: 193354-13-1Purity: >99.00%
5-Iodoindolin-2-one (5-iodo-2,3-dihydro-1H-indol-2-one) is an intermediate that can be used in the synthesis of degraders, such as KRAS degrader-1 [1] .
- GC80159Famotidine impurity 8CAS: 107880-74-0Purity: >98.00%
Famotidine impurity 8 (Famotidine propionic acid) is an impurity of Famotidine.
- GC80160Acyclovir impurity 11CAS: 102728-64-3Purity: >98.00%
Acyclovir impurity 11 is an impurity of Acyclovir.
- GC80161Ketoprofen impurity 4CAS: 107257-20-5Purity: >98.00%
Ketoprofen impurity 4 (rac-4’-Methyl ketoprofen) is an impurity of Ketoprofen.
- GC80162Boc-3,3-DicPr-Ala-OHCAS: 2548967-22-0Purity: >98.00%
Boc-3,3-DicPr-Ala-OH is a chiral amino acid intermediate used in the synthesis of IL-17 modulators.
- GC80163Sertraline impurity 7CAS: 52758-05-1Purity: >99.50%
Sertraline impurity 7 (rac-cis-3,4-Deschlorosertraline) is an impurity of Sertraline.
- GC80164Candesartan impurity 32CAS: 596-31-6Purity: >98.00%
(Methoxymethanetriyl)tribenzene (Methyl trityl ether) is a drug impurity.
- GC80165Bupropion impurity 7CAS: 1049718-72-0Purity: >99.50%
Bupropion impurity 7 is an impurity of Bupropion.
- GC80166Methotrexate impurity 7CAS: 52980-68-4Purity: >98.00%
Methotrexate impurity 7 is an impurity of Methotrexate.
- GC80167Ketoprofen impurity 10CAS: 60658-04-0Purity: >98.00%
Ketoprofen impurity 10 is an impurity of Ketoprofen.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC80144 | Aripiprazole impurity 9 | 57260-67-0 | >99.50% | |
Aripiprazole impurity 9 is an impurity of Aripiprazole. | ||||
| GC80145 | 2-(6-Bromo-1H-indol-3-yl)acetonitrile | 152213-61-1 | >98.00% | |
2-(6-Bromo-1H-indol-3-yl) acetonitrile is an intermediate that participates in the synthesis of MKlp2 inhibitors. | ||||
| GC80146 | Aripiprazole impurity 35 | 889443-20-3 | >98.00% | |
Aripiprazole impurity 35 is an impurity of Aripiprazole. | ||||
| GC80147 | Paliperidone impurity 9 | 260273-82-3 | >98.00% | |
Paliperidone impurity 9 is an impurity of Paliperidone. | ||||
| GC80148 | Albendazole impurity 9 | 80983-34-2 | >98.50% | |
6-(Propylsulfonyl)-1H-benzimidazol-2-amine (Albendazole-2-aminosulfone) is a drug impurity. | ||||
| GC80149 | FPPS ligand 3 | 51527-19-6 | >98.00% | |
FPPS ligand 3 (compound 2) is a farnesyl pyrophosphate synthase (FPPS) ligand. | ||||
| GC80150 | Paliperidone impurity 17 | 130049-82-0 | >97.00% | |
Paliperidone impurity 17 is an impurity of Paliperidone. | ||||
| GC80151 | Metoprolol impurity 3 hydrochloride | 73313-36-7 | >98.00% | |
Metoprolol impurity 3 hydrochloride is an impurity of Metoprolol hydrochloride. | ||||
| GC80152 | 2,4'-Dichlorobenzophenone | 85-29-0 | >98.50% | |
2,4'-Dichlorobenzophenone is a dichlorinated benzophenone and intermediate in the synthesis of selected fungicides and other agricultural products [1] . | ||||
| GC80153 | H-Pro-His-OH | 92027-43-5 | >98.00% | |
H-Pro-His-OH is a commonly used amino acid building block in biochemistry and peptide synthesis. | ||||
| GC80154 | Atenolol impurity 2 | 1797116-92-7 | >98.00% | |
Atenolol impurity 2 (C-Desmethyl atenolol) is an impurity of Atenolol. | ||||
| GC80155 | Lincomycin impurity 2 | 14810-93-6 | >98.00% | |
Lincomycin impurity 2 (Methyl 1-thiolincosaminide) is an impurity of Lincomycin. | ||||
| GC80156 | 3,2'-Dihydroxyflavone | 6068-76-4 | >99.00% | |
3,2'-Dihydroxyflavone (Compound 4) is a type of flavonol compound that can be used as a drug intermediate for the synthesis of tetracyclic compounds [1] . | ||||
| GC80157 | Elymoclavine | 548-43-6 | >98.00% | |
Elymoclavine, an ergot alkaloid, is a potential prolactin inhibitor. | ||||
| GC80158 | 5-Iodoindolin-2-one | 193354-13-1 | >99.00% | |
5-Iodoindolin-2-one (5-iodo-2,3-dihydro-1H-indol-2-one) is an intermediate that can be used in the synthesis of degraders, such as KRAS degrader-1 [1] . | ||||
| GC80159 | Famotidine impurity 8 | 107880-74-0 | >98.00% | |
Famotidine impurity 8 (Famotidine propionic acid) is an impurity of Famotidine. | ||||
| GC80160 | Acyclovir impurity 11 | 102728-64-3 | >98.00% | |
Acyclovir impurity 11 is an impurity of Acyclovir. | ||||
| GC80161 | Ketoprofen impurity 4 | 107257-20-5 | >98.00% | |
Ketoprofen impurity 4 (rac-4’-Methyl ketoprofen) is an impurity of Ketoprofen. | ||||
| GC80162 | Boc-3,3-DicPr-Ala-OH | 2548967-22-0 | >98.00% | |
Boc-3,3-DicPr-Ala-OH is a chiral amino acid intermediate used in the synthesis of IL-17 modulators. | ||||
| GC80163 | Sertraline impurity 7 | 52758-05-1 | >99.50% | |
Sertraline impurity 7 (rac-cis-3,4-Deschlorosertraline) is an impurity of Sertraline. | ||||
| GC80164 | Candesartan impurity 32 | 596-31-6 | >98.00% | |
(Methoxymethanetriyl)tribenzene (Methyl trityl ether) is a drug impurity. | ||||
| GC80165 | Bupropion impurity 7 | 1049718-72-0 | >99.50% | |
Bupropion impurity 7 is an impurity of Bupropion. | ||||
| GC80166 | Methotrexate impurity 7 | 52980-68-4 | >98.00% | |
Methotrexate impurity 7 is an impurity of Methotrexate. | ||||
| GC80167 | Ketoprofen impurity 10 | 60658-04-0 | >98.00% | |
Ketoprofen impurity 10 is an impurity of Ketoprofen. | ||||