SLMP53-1 |
| Catalog No.GC65284 |
SLMP53-1 est un réactivateur de p53 de type sauvage et mutant avec une activité antitumorale prometteuse. SLMP53-1 intervient dans la reprogrammation du métabolisme du glucose dans les cellules cancéreuses. SLMP53-1 épuise l'angiogenèse, diminuant la formation de tubes de cellules endothéliales et les niveaux d'expression du facteur de croissance endothélial vasculaire (VEGF).
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Cas No.: 1643469-17-3
Sample solution is provided at 25 µL, 10mM.
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SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].
[1]. Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151.
[2]. Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21(2):596.
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