SLMP53-1 |
| カタログ番号GC65284 |
SLMP53-1 は、有望な抗腫瘍活性を持つ野生型および変異型 p53 再活性化因子です。 SLMP53-1 は、がん細胞におけるグルコース代謝の再プログラミングを仲介します。 SLMP53-1 は血管新生を枯渇させ、内皮細胞の管形成と血管内皮増殖因子 (VEGF) の発現レベルを低下させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1643469-17-3
Sample solution is provided at 25 µL, 10mM.
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SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].
[1]. Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151.
[2]. Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21(2):596.
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