Theaflavin 3,3'-digallate (Synonyms: TF3, TFDG) |
| Catalog No.GC41573 |
Le 3,3'-digallate de théaflavine (TF-3) est un puissant inhibiteur de la protéase du virus Zika (ZIKV) avec une IC50 de 2,3 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30462-35-2
Sample solution is provided at 25 µL, 10mM.
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Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 µmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 µM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.
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