Tos-PEG4-t-butyl ester |
| Catalog No.GC38867 |
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) est un lieur PROTAC, qui fait référence À la composition du PEG. Le Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) peut être utilisé dans la synthèse d'une série de PROTAC, comme le BI-3663. BI-3663 est un PTK2/FAK PROTAC hautement sélectif, avec des ligands cereblon pour détourner les ligases E3 pour la dégradation de PTK2, et inhibe PTK2 avec une IC50 de 18 nM.
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Cas No.: 217817-01-1
Sample solution is provided at 25 µL, 10mM.
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Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 . BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
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