Valecobulin hydrochloride (Synonyms: CKD-516 hydrochloride) |
| Catalog No.GC39177 |
Le chlorhydrate de valécobuline (chlorhydrate de CKD-516) est un promédicament valine de S516 et un agent perturbateur vasculaire (VDA). Le chlorhydrate de valécobuline est un puissant inhibiteur de la polymérisation de la β-tubuline avec une activité antitumorale marquée contre les tumeurs solides murines et humaines.
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Cas No.: 1240321-53-2
Sample solution is provided at 25 µL, 10mM.
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Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2].
[1]. Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54. [2]. Joo I, et al. Intravoxel incoherent motion diffusion-weighted MR imaging for monitoring the therapeutic efficacy of the vascular disrupting agent CKD-516 in rabbit VX2 liver tumors. Radiology. 2014 Aug;272(2):417-26.
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