VU0360172 |
| Catalog No.GC64513 |
VU0360172 est un modulateur allostérique positif puissant et sélectif du récepteur mGlu5 avec une valeur EC50 de 16 nM et un Ki de 195 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1310012-12-4
Sample solution is provided at 25 µL, 10mM.
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VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.
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