VU0360172 |
| Catalog No.GC64513 |
VU0360172는 각각 EC50 값이 16nM이고 Ki가 195nM인 강력하고 선택적인 mGlu5 수용체 양성 알로스테릭 조절제입니다.
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Cas No.: 1310012-12-4
Sample solution is provided at 25 µL, 10mM.
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VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.
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