XPC-6444 |
| Catalog No.GC63261 |
XPC-6444 est un inhibiteur de NaV1.6 très puissant, sélectif des isoformes et pénétrant dans le SNC (IC50 = 41 nM pour hNaV1.6).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2230144-21-3
Sample solution is provided at 25 µL, 10mM.
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XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1].
XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1].
XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1].
[1]. Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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