XPC-6444 |
| カタログ番号GC63261 |
XPC-6444 は、非常に強力なアイソフォーム選択的で CNS 浸透性の NaV1.6 阻害剤です (hNaV1.6 の IC50 = 41 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2230144-21-3
Sample solution is provided at 25 µL, 10mM.
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XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1].
XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1].
XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1].
[1]. Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.
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