Z62954982 (Synonyms: ZINC08010136) |
| Catalog No.GC39763 |
Le Z62954982 (ZINC08010136) est un inhibiteur de Rac1 (IC50=12μM) puissant, sélectif et perméable aux cellules qui est 4fois plus efficace que le NSC23766 (IC50=50μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1090893-12-1
Sample solution is provided at 25 µL, 10mM.
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Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA)[1][2].
[1]. Nicola Ferri,et al. Virtual Screening Approach for the Identification of New Rac1 Inhibitors. J Med Chem. 2009 Jul 23;52(14):4087-90. [2]. Xun E Zhang, et al. Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. PLoS One. 2016 May 17;11(5):e0155490. [3]. Min Yu, et al. Lack of BCR and Abr Promotes Hypoxia-Induced Pulmonary Hypertension in Mice. PLoS One
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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