AE 51310 |
カタログ番号GB40093
One-Click Copy Product Info
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AE 51310（433966-92-8）は、GPCR OPN4 / melanopsinの強力な拮抗剤です（Ki = 0.096 nM人間OPN4）。 OPN4は、循環リズム、瞳孔機能、メラトニン発現、認知および睡眠を調節します。 肺がん細胞でGa11に結合し、PKC活性化を修飾してBRAF / MEK / ERKシグナル伝達経路の活性化につながることがわかっています。 AE 51310はマウスキセノグラフトモデルでLG17およびLG55肺がん腫瘍の成長と増殖を減少させました。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 433966-92-8
Sample solution is provided at 25 µL, 10mM.
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AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4). OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to bind Ga11 in lung cancer cells modulating PKC activation leading to activation of BRAF/MEK/ERK signaling pathways. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.
| Cas No. | 433966-92-8 | SDF | |
| Formula | C14H17Cl2NO3S | M.Wt | 338.24 |
| 溶解度 | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9565 mL | 14.7824 mL | 29.5648 mL |
| 5 mM | 591.3 μL | 2.9565 mL | 5.913 mL |
| 10 mM | 295.6 μL | 1.4782 mL | 2.9565 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)