Blosozumab |
| カタログ番号GC66384 |
ブロソズマブ (LY2541546) は、抗ヒト スクレロスチン (SOST) 抗体阻害剤です。ブロソズマブは骨形成を刺激し、骨吸収を減少させます。ブロソズマブは、骨粗鬆症の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1132758-87-2
Sample solution is provided at 25 µL, 10mM.
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Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].
Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].
| Animal Model: | Sprague-Dawley rats [2] |
| Dosage: | 1, 10, and 100 mg/kg |
| Administration: | Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study) |
| Result: | Observed the bone anabolic effects. Showed significant bleeding and morbidity at 100 mg/kg. Decreases in the numbers of platelets. Increased number of bone marrow megakaryocytes at 100 mg/kg. |
Review for Blosozumab
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Blosozumab
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