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(-)-Cryptopleurine (Synonyms: (R)-Cryptopleurine, NSC 19912)

カタログ番号GC48635

多様な生物学的活性を持つアルカロイド

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(-)-Cryptopleurine 化学構造

Cas No.: 482-22-4

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1mg
$375.00
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5mg
$1,314.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

(-)-クリプトプレウリンは、Lauraceaeに見つかったアルカロイドであり、多様な生物学的活性を持っています。1 それは人間のA375メラノーマ、A431表皮癌、A549肺がん、MES-SA子宮肉腫、およびMCF-7乳がん細胞の成長を抑制します(すべてのIC50=3 nM)。2 (-)-クリプトプレウリンは低酸素応答要素(HRE)報告者アッセイで低酸素誘導遺伝子発現を阻害します(IC50=8.7 nM)。</sup><p><-) -クリプトプレウリン(500μg/ml)はタバコモザイクウイルス(TMV)に感染したタバコ(<i>N. tabacum</i>)植物の病変形成を防止します。</sup> それは酵母および哺乳類リボソームによるタンパク質合成も抑制します。,

1. Wang, Z., Feng, A., Cui, M. 他、フェナントロキノリジジンを新規抗ウイルス剤としてタバコモザイクウイルス(TMV)に対する構造活性関係研究を初めて発見。PLoS One7(12)e52933(2012) 2. Banwell, M.G., Bezos, A., Burns, C. 他、強力な抗血管新生作用を示すフェナントロキノリジジンアルカロイドのjulandineおよびcryptopleurineのC8c-C15単離体類似体。Bioorg。Med.Chem.Lett.16(1)181-185(2006) 3.Cai,X.F.、Jin,X.、Lee,D. 他、Boehmeria pannosa根から分離されたフェナントロキノリジジンアルカロイドはAGS人間胃がん細胞で低酸素誘導性因子-1を強力に阻害する。J.Nat.Prod .69(7)1095-1097(2006) 4.Battaner,E.and Vazquez,D.Ribosomes of the80-S typeによるタンパク質合成の阻害剤。Biochim.Biophys.Acta254(2)316-330(1971) 5.Pestka,S.Rosenfeld,H.Harris,R. 他、転移RNA-リボソーム複合体に関する研究。XXI.哺乳動物のポリリボソームによるペプチドル-プロマイシン合成への抗生物質の影響。J.Biol.Chem .247(21)6895-6900(1972)

Chemical Properties

Cas No. 482-22-4 SDF
同義語 (R)-Cryptopleurine, NSC 19912
Canonical SMILES COC1=CC2=C3C(CN4[C@@](CCCC4)([H])C3)=C5C(C=C(C=C5)OC)=C2C=C1OC
Formula C24H27NO3 M.Wt 377.5
溶解度 Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.649 mL 13.245 mL 26.4901 mL
5 mM 0.5298 mL 2.649 mL 5.298 mL
10 mM 0.2649 mL 1.3245 mL 2.649 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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