[D-Lys3]-GHRP-6 (trifluoroacetate salt) (Synonyms: D-Lys3-Growth Hormone Releasing Peptide 6, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2) |
| カタログ番号GC52388 |
GHS-R1aの拮抗剤
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![[D-Lys3]-GHRP-6 (trifluoroacetate salt) 化学構造](/media/struct/GC5/GC52388.png "[D-Lys3]-GHRP-6 (trifluoroacetate salt) 化学構造")
Sample solution is provided at 25 µL, 10mM.
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[D-Lys3]-GHRP-6 is an antagonist of the growth hormone secretagogue receptor 1a (GHS-R1a; Ki = 4.25 nM).1 It inhibits ghrelin-induced cAMP accumulation in human aortic smooth muscle cells when used at a concentration of 20 nM. [D-Lys3]-GHRP-6 (12 mg/kg) decreases food intake in Zucker FA/FA lean and fa/fa obese rats.2
1.Rossi, F., Castelli, A., Bianco, M.J., et al.Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activationAtherosclerosis203(1)97-104(2008) 2.Beck, B., Richy, S., and Sticker-Krongrad, A.Feeding response to ghrelin agonist and antagonist in lean and obese Zucker ratsLife Sci.76(4)473-478(2004)
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