Dienamide A2 (Synonyms: (2E,4E)-N-Isobutyldodeca-2,4-dienamide) |
カタログ番号GB40178
One-Click Copy Product Info
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ダイエンアミドA2（24738-51-0）は、エキナセアに存在する天然のアミドの類似体であり、新しいカンナビノミメティック化合物の一種です。この化合物クラスは、CB2受容体を介して人間の単球/マクロファージにおけるTNFα mRNA発現を調節します。ダイエンアミドA2は内因性カンナビノイドよりも大きな親和性でカンナビノイド受容体に結合します（CB2とCB1それぞれに対してKi =〜60および> 1500 nM）。それはCB2陽性細胞では細胞内Caレベルを上昇させますが、CB2陰性細胞ではその効果がSR144528によって阻止されました。また、それはCB2非依存的な方法でLPS誘導性TNFαおよびIL-1β発現を有意に抑制します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 24738-51-0
Sample solution is provided at 25 µL, 10mM.
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Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor. Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively). It elevates intracellular Ca levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528. It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.
| Cas No. | 24738-51-0 | SDF | |
| 同義語 | (2E,4E)-N-Isobutyldodeca-2,4-dienamide | ||
| Formula | C16H29NO | M.Wt | 251.41 |
| 溶解度 | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9776 mL | 19.8878 mL | 39.7757 mL |
| 5 mM | 795.5 μL | 3.9776 mL | 7.9551 mL |
| 10 mM | 397.8 μL | 1.9888 mL | 3.9776 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)