DS44960156 |
| カタログ番号GC47274 |
DS44960156 は選択的メチレンテトラヒドロ葉酸デヒドロゲナーゼ 2 (MTHFD2) 阻害剤で、MTHFD2 と MTHFD1 の IC50 値はそれぞれ 1.6 μM と >30 μM です 。
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Cas No.: 2361327-08-2
Sample solution is provided at 25 µL, 10mM.
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DS44960156 is an inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2; IC50 = 1.6 µM).1 It is selective for MTHFD2 over MTHFD1 (IC50 = >30 µM).
1.Kawai, J., Ota, M., Ohki, H., et al.Structure-based design and synthesis of an isozyme-selective MTHFD2 inhibitor with a tricyclic coumarin scaffoldACS Med. Chem. Lett.10(6)893-898(2019)
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