Exo2 (Synonyms: 2-Methoxy-4-[(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol) |
カタログ番号GB40194
One-Click Copy Product Info
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Exo2（304684-77-3）は、哺乳動物細胞のゴルジ体を妨害し、ゴルジ体とERの融合を促進します。ゴルジ体を完全に消滅させるために使用されることがあります。ブレフェルディンA（BFA）と同様に、前行性輸送を阻害し、トランス・ゴルジ網（TGN）の形態を妨げますが、BFAとは異なり、TGNおよびエンドソーム区画のチューブ化や統合を誘導しません。シーガ毒素のエンドソームからトランス・ゴルジ網への移行を妨げ、コレラ毒素とは対照的です。perilipin-2タンパク質の分解を加速します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 304684-77-3
Sample solution is provided at 25 µL, 10mM.
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Exo2 (304684-77-3) disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells. May be used to completely ablate the Golgi apparatus. Like brefeldin A (BFA), it inhibits anterograde transport and disrupts morphology of the trans-Golgi network (TGN) but unlike BFA, it does not induce tubulation and merging of the TGN and endosomal compartments. It perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network, in contrast to cholera toxin. Accelerates degradation of perilipin-2 proteins.
| Cas No. | 304684-77-3 | SDF | |
| 同義語 | 2-Methoxy-4-[(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol | ||
| Formula | C18H18N4O2S | M.Wt | 354.43 |
| 溶解度 | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8214 mL | 14.1072 mL | 28.2143 mL |
| 5 mM | 564.3 μL | 2.8214 mL | 5.6429 mL |
| 10 mM | 282.1 μL | 1.4107 mL | 2.8214 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)