Hepcidin-25 (human) |
カタログ番号GA22331
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ヘプシジン-25（肝臓細菌殺性タンパク質）は、人間の血液超濾過物と尿中で独立して発見されたLEAP-1（肝臓発現抗微生物ペプチド）とも呼ばれます。このペプチドは主に肝臓で発現し、8つのシステイン残基を含む新しい脊椎動物家族の小さな抗微生物ペプチドに属し、有意な抗菌および抗真菌活性を示します。さらなる調査により、ヘピシジンが人間における主要な鉄代謝調節ホルモンであることが明らかになりました。ヘピシジンは鉄排出ポートFerroportinに結合してその内在化と分解を引き起こし、細胞内からの鉄排出を阻止することで作用します。Nemethらは、ペプチドホルモンのN末端部分がその活性に必須であることを実証しました。 旧CAS番号342790-21-0です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1356390-47-0
Sample solution is provided at 25 µL, 10mM.
Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the l
| Cas No. | 1356390-47-0 | SDF | |
| Formula | C113H170N34O31S9 | M.Wt | 2789.4 |
| 溶解度 | soluble in 1% Acetic Acid in 1mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 358.5 μL | 1.7925 mL | 3.585 mL |
| 5 mM | 71.7 μL | 358.5 μL | 717 μL |
| 10 mM | 35.9 μL | 179.3 μL | 358.5 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)